The advent of cutting-edge digitalization has introduced a range of organizational capabilities that have been proposed to assist business-to-business (B2B) manufacturers in attaining a strategic advantage within the intensely competitive global landscape. Nevertheless, the process of digitization poses multiple roadblocks in its execution, leading to a sense of scepticism among manufacturers in the B2B sector about its adoption for the purpose of enhancing their quality management and agility across the supply chain. The current research is a pioneering effort in examining the interplay between digital dexterity (DigDex), supply chain quality management (SCQM), supply chain agility (SCAG), and supply chain performance (SCP) within the distinctive sphere of B2B manufacturing. In order to gain a deeper comprehension of the efficacy of the interplay between various functional capabilities, this study investigates the effectiveness of regulatory governance in providing assistance to B2B manufacturers. This examination is conducted through empirical analysis utilizing data collected from a sample of 291 B2B manufacturers based in India. The research advances the understanding of the mechanisms by which DigDex, SCQM, and SCAG interact for bettering SCP. Practically, these findings guide practitioners to optimize digital capabilities judiciously, tailoring regulatory governance approaches for comprehensive supply chain enhancement in the dynamic B2B manufacturing landscape