Ancient trade relations gave way to interesting religious mixing, as people traversed across long stretches of land masses or water bodies — taking with them their religious beliefs and world views. The intermixing, in turn, left material imprints or signatures that are of relevance to archaeologists and historians of our contemporary times — interested in tracing movement of people and their convictions. This essay explores ancient trade linkages that existed between: a) the Indus cities — that flourished during the second half of the third millennium BCE — and the Bactria-Margiana Archaeological Complex (BMAC) in Central Asia, which included parts of present-day Turkmenistan, northern Afghanistan, northeastern Iran, southern Uzbekistan, and western Tajikistan and b) Mesopotamia (parts of present-day Iraq, Kuwait, Türkiye, and Syria) and the Indus sites. The focus of deliberative endeavor will be on a particular motif — Mistress/Master of Animals/Lord of Animals — discovered on antique seals.