Information Technology (IT) is rapidly transforming higher education (HE). Past studies concluded that IT positively influences HE students’ learning outcomes. However, these studies either focused on specific IT or utilized formal classroom setting. The present study overcomes these limitations, along with drawing implications by analyzing 72 quantitative peer-reviewed articles. It reveals that: (a) IT highly enhances learning outcomes education subject, while moderately for language, medical and nursing subjects. The learning outcomes for science and technology subjects are low; (b) unexpectedly, general applications are more effective than learning-oriented applications; (c) formal learning environment is more effective; and (d) learning outcomes are higher for longer intervention period (> 1 month) than smaller intervention period (≤ 24 hours).