Virtual reality as a channel of communication for health education among media audiences is a unique modern-day technology that has the potential to change the way health information is communicated and learned. This study examines the influence of virtual reality as a communication channel for health education among the media audience in Southwest Nigeria. The study employs a survey research method, gathering data from the population of Lagos residents. Copies of the questionnaire are administered to a sample size of 400 respondents in Lagos State to elicit information from them. The study reveals that high awareness of virtual reality, moderate cultural relevance, and significant influence on health behaviours, although challenges such as cost and access remain barriers. The high level of awareness suggests that the media audience is beginning to understand new digital developments in health communication. Statistical analysis reveals that cultural relevance has significant predictive power for the educational impact of virtual reality. In conclusion, the study affirms that virtual reality is a transformative health education tool when culturally adapted and adequately supported by infrastructure and awareness. Therefore, being exposed to virtual reality health content changes life choices and improves health behaviour. This study indicates that virtual reality can effectively transpose cultural significance when integrated and presented, and when relevant and accessible, can reduce barriers and communicate to audiences with different literacy levels.