This chapter explores the policy and regulatory frameworks necessary for managing the impact of artificial intelligence (AI) on the global workforce. As AI technologies reshape industries, they present both opportunities and challenges, including labor displacement, ethical dilemmas, and regulatory fragmentation. The chapter examines the role of AI in transforming global work, highlighting key challenges such as fairness, transparency, and accountability in AI systems. It discusses policy frameworks from different global perspectives and the need for international collaboration to harmonize AI regulations. Furthermore, the chapter emphasizes the importance of human-centric AI policies that prioritize worker protection, ethical development, and equitable access. Key recommendations include investing in reskilling, establishing social safety nets, and fostering global cooperation to create a sustainable and inclusive future of work. This comprehensive approach aims to ensure that AI benefits workers and society, while mitigating potential risks.