This chapter explores effective strategies for managing stress and preventing burnout among entrepreneurs. Given the unique challenges faced in entrepreneurship, understanding the factors contributing to stress is essential. The discussion includes various stress management techniques, such as mindfulness practices, organizational support, and technological tools that enhance productivity and well-being. Future trends, including the integration of artificial intelligence and a focus on holistic wellness, highlight the evolving landscape of stress management. By prioritizing mental health, entrepreneurs can foster resilience, improve work-life balance, and create supportive environments for themselves and their teams. This chapter aims to equip entrepreneurs with actionable insights to navigate their entrepreneurial journey while safeguarding their mental health.