This chapter explores the critical impact of wellness programs on entrepreneurial burnout, emphasizing their role in promoting resilience and sustainable business practices. As entrepreneurs face unique pressures that contribute to stress and burnout, effective wellness initiatives become essential for enhancing overall well-being. This study evaluates various types of wellness programs, innovative digital solutions, and their long-term effects on entrepreneurial sustainability. Additionally, it addresses the challenges of implementing these programs and highlights the need for supportive policies and community involvement. Future trends indicate a shift towards personalized, technology-driven wellness solutions that foster holistic health. By prioritizing wellness, entrepreneurs can cultivate healthier work environments, ultimately leading to increased productivity and business success.