This chapter explores the profound effects of financial stress on the mental health of entrepreneurs, highlighting how chronic financial pressures can impair decision-making, foster burnout, and strain personal and professional relationships. Untreated financial stress can lead to long-term mental health issues such as anxiety and depression, adversely impacting both the individual and their business. The chapter examines the role of financial literacy and support systems in mitigating stress, emphasizing the importance of proactive strategies to manage financial challenges. It also discusses the importance of resilience and coping mechanisms in protecting entrepreneurs' mental health and sustaining business performance. Ultimately, the chapter underscores the need for greater awareness and support in addressing financial stress to ensure long-term entrepreneurial success and well-being