This research article conducts a comparative analysis of institutional reform and governance effectiveness, and its implications for spatial planning and regional development across ten diverse developing countries. It scrutinizes governance frameworks, macroeconomic policies, policy outcomes, and land-use planning disparities, infrastructure accessibility, and urban-rural integration challenges. Political stability, institutional capacity, and policy implementation significantly shape regional development outcomes. Countries like Botswana and Chile demonstrate successful governance-linked spatial growth, while nations such as Myanmar and Zimbabwe struggle with governance-induced development bottlenecks. The study underscores the role of governance in planning sustainable cities, reducing regional inequalities, and fostering inclusive socio-economic progress across diverse geographies.