“Human Rights and Islamic Business: Towards Sustainability” delves into the intricate relationship between human rights principles and Islamic business practices in Indonesia, with a keen focus on the pivotal role played by the Business and Human Rights Risk Assessment (PRISMA) application in fostering sustainable business practices. This study meticulously scrutinizes how PRISMA can serve as an instrumental tool for businesses to meticulously assess and effectively mitigate human rights risks in their operational frameworks, thus harmonizing with Islamic principles and international human rights standards. Indonesia's unwavering commitment to embedding human rights principles within the fabric of business operations is prominently showcased through the issuance of Presidential Regulation No. 60 of 2023 on the National Strategy on Business and Human Rights (Stranas BHAM). This regulation serves as a pivotal cornerstone in the integration of human rights principles into the nation's business landscape.