This paper provides an overview of a transnational research project exploring the impact of the COVID-19 pandemic, and public health responses to it, on sexual and gendered politics. It sets out a framework for rethinking sexual and intimate citizenship during the COVID-19 pandemic, and draws on examples from India, Italy, Mexico and the UK to illustrate our analysis. We examine how the pandemic has impacted on the everyday negotiation of intimacy and highlighted material inequalities that impact on the lives of women and LGBTQ+ people. We argue that the pandemic has produced new faultlines between women and different groups of LGBTQ+ people, as well as amplifying existing tensions. In addition to identifying these faultlines, we explore the cracks opened by them which might reveal possibilities for new coalitions and alliances in relation to sexual and gendered politics.