Blockchain technology is considered a disruptive innovation that changes the ways companies and global processes operate. This technology has impressive powers to change this world for the better. This book examines the origins, emergence, challenges, and opportuni‑ ties in the blockchain field, rethinking business strategy and readiness in the digital world and how blockchain technology would improve businesses. It provides a blockchain readiness model for managing supply chains and reviews enabling technologies such as AI, big data, and organisational capa‑ bilities that support the adoption of blockchain technology. Through innova‑ tive design and simulation of a blockchain framework, it aims to enhance the traceability and transparency of business operations and supply chains. This includes developing key performance indicators for measuring the seamless integration of blockchain technology and achieving a successful outcome. It explores how blockchain technology enhances the green and sustainability aspects of businesses by comparing the sectors and discussing the poten‑ tial for blockchain to promote a green and sustainable economy. This book concludes with research frontiers and blockchain applications in healthcare, international trade, and supply chain sectors.