This paper examines the impact of Entrepreneurial Orientation (EO) on the development and retention of supply chain talent within global organizations. By analyzing how EO influences innovation, operational efficiency, and employee engagement, the research reveals that EO plays a vital role in empowering supply chain professionals to take risks, develop new skills, and lead strategic initiatives. The findings suggest that EO contributes significantly to building resilient and adaptable supply chains while enhancing talent retention by creating a fulfilling work environment. However, the study also identifies limitations in the universal application of EO, particularly in smaller firms or varying cultural contexts, and outlines directions for future research. This paper provides essential insights for both academics and practitioners on how to effectively integrate EO into supply chain talent management strategies for sustainable competitive advantage.