Integrating knowledge management (KM) with sustainability in entrepreneurial supply chains is crucial for enhancing operational efficiency and achieving long-term success. This chapter explores how KM systems can support sustainability by facilitating the capture, organization, and application of sustainability-related knowledge. It highlights the benefits of KM, such as improved transparency, data-driven decision-making, and enhanced collaboration among stakeholders. The chapter also addresses key challenges, including technological limitations, resource constraints, and cultural resistance. Emerging trends like advanced technologies, circular economy models, and increased focus on social sustainability are discussed as future directions for integrating KM and sustainability. By leveraging KM effectively, entrepreneurial firms can drive innovation, optimize processes, and build resilient supply chains, contributing to both business success and environmental stewardship.