The integration of digitalization and Knowledge Management (KM) is revolutionizing supply chain management by enhancing efficiency, agility, and transparency. This chapter explores the transformative impact of digital technologies—such as AI, IoT, blockchain, and advanced analytics—on supply chain operations. It examines how these technologies, when combined with robust KM practices, facilitate real-time data-driven decision-making and improve operational processes. Key trends and innovations, including the use of digital twins, augmented reality (AR), and 5G, are discussed, highlighting their potential to address existing challenges and drive future advancements. The chapter also addresses barriers such as cultural resistance, data security, and infrastructure costs. By analyzing case studies from leading organizations, it provides insights into successful integration strategies and the strategic advantages of leveraging digitalization and KM. The conclusion emphasizes the importance of staying adaptable and proactive to harness the full potential of these advancements.