This chapter explores the role of Entrepreneurial Orientation (EO) in strengthening supply chain collaboration and interorganizational networks. EO, encompassing innovativeness, proactiveness, and risk-taking, significantly impacts supply chain performance by fostering innovation, enhancing agility, and facilitating bold strategies. The chapter examines the theoretical underpinnings of EO, mechanisms through which EO influences supply chain practices, and practical case studies from firms like Tesla, Zara, Alibaba, Unilever, and Amazon. It identifies challenges and barriers such as potential conflicts, balancing EO with supply chain stability, and organizational culture issues. Emerging trends, including digital transformation, sustainability, and the role of AI and big data, are discussed as key drivers shaping the future of EO-driven supply chain management. The chapter concludes with insights on the implications for theory and practice, and recommendations for future research, highlighting the importance of EO in achieving resilient and adaptive supply chains.