This chapter explores the transition to circular supply chain entrepreneurship, highlighting its significance in achieving sustainability and economic resilience. By shifting from linear models of “take, make, dispose” to circular practices, businesses can enhance resource efficiency, reduce waste, and create new revenue streams. The chapter addresses key barriers such as high costs, logistical complexities, and consumer awareness, offering strategies for overcoming these challenges through technology, collaboration, and supportive policy frameworks. Case studies and best practices provide practical insights into successful circular supply chains. Looking ahead, emerging trends like digitalization, evolving business models, and changing consumer behaviors are expected to shape the future of circular entrepreneurship. The role of policy and governance is crucial in facilitating this transition, providing the necessary support for businesses to thrive in a circular economy.