This chapter focuses on stigma and discrimination related to adults with psychosocial disabilities in low- and middle-income countries (LMICs). People with mental disorders are much likely to be unemployed, poor, disadvantaged and treated unequally than poeple without such conditions. To illustrate these key points, research related to stigma and discrimination from three regions, South and South East Asia, North Africa and the Middle East Asia, and sub-Saharan Africa has been highlighted. This chapter discusses the need for interventions, future research, human rights and policy priorities in LMIC settings.