Is it too early to recommend local treatment in oligometastatic NSCLC: a plea for equipoise

Ahmad, Irfan, Chufal, Kundan Singh, Miller, Alexis Andrew, Bajpai, Ram, Umesh, Preetha, Dawer, Aashita, Tandon, Sarthak, Gandhidasan, Senthilkumar, Dua, Bharat, Bhatia, Kratika and Gairola, Munish (2024) Is it too early to recommend local treatment in oligometastatic NSCLC: a plea for equipoise. British Journal of Radiology. ISSN 0007-1285 (In Press)

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Abstract

Oligometastatic Non-Small Cell Lung cancer (OMD NSCLC) has been proposed to bridge the spectrum between non-metastatic to widely metastatic states and is perceived as an opportunity for potential cure if removed. Twelve clinical trials on local treatment have been reported, yet none are conclusive. These trials informed the development of a joint clinical practice guideline (CPG) by the American & European societies for radiation oncology, which endorses local treatment for OMD NSCLC. However, the heterogeneity between and prognostic factors within these trials likely influenced outcomes and can only support guidance at this time. Caution against an uncritical acceptance of the guideline is discussed, as strong recommendations are offered based on expert opinion and inconclusive evidence. The guideline is also examined by a patient’s caregiver, who emphasizes that uncertain evidence impedes shared decision-making

Item Type: Article
Keywords: Oligometastatic Non-Small Cell Lung cancer (OMD NSCLC) | Clinical practice guideline (CPG) |
Subjects: Physical, Life and Health Sciences > Medicine
Social Sciences and humanities > Social Sciences > Social Sciences (General)
Social Sciences and humanities > Social Sciences > Health (Social sciences)
JGU School/Centre: Jindal Global Law School
Depositing User: Subhajit Bhattacharjee
Date Deposited: 30 Mar 2024 09:57
Last Modified: 30 Mar 2024 09:57
Official URL: https://doi.org/10.1093/bjr/tqae068
URI: https://pure.jgu.edu.in/id/eprint/7548

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