Molecular hybridization of Alkaloids using 1,2,3-Triazole-based click Chemistry

Buchanan, Devan, Pham, Ashley M., Singh, Sandeep Kumar and Panda, Siva S. (2023) Molecular hybridization of Alkaloids using 1,2,3-Triazole-based click Chemistry. Molecules, 28 (22): 7593. ISSN 1420-3049

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Alkaloids found in multiple species, known as ‘driver species’, are more likely to be included in early-stage drug development due to their high biodiversity compared to rare alkaloids. Many synthetic approaches have been employed to hybridize the natural alkaloids in drug development. Click chemistry is a highly efficient and versatile reaction targeting specific areas, making it a valuable tool for creating complex natural products and diverse molecular structures. It has been used to create hybrid alkaloids that address their limitations and serve as potential drugs that mimic natural products. In this review, we highlight the recent advancements made in modifying alkaloids using click chemistry and their potential medicinal applications. We discuss the significance, current trends, and prospects of click chemistry in natural product-based medicine. Furthermore, we have employed computational methods to evaluate the ADMET properties and drug-like qualities of hybrid molecules

Item Type: Article
Keywords: heterocycles | 1,2,3-triazole | alkaloids | biological properties | molecular hybridization | click chemistry | ADMET properties
Subjects: Physical, Life and Health Sciences > Medicine
Physical, Life and Health Sciences > Biology
Physical, Life and Health Sciences > Chemistry
JGU School/Centre: Jindal Global Business School
Depositing User: Subhajit Bhattacharjee
Date Deposited: 28 Dec 2023 09:17
Last Modified: 28 Dec 2023 09:17
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