In this article, we present the effect on GDP growth rate during key major pandemics in the twenty-first century. Ebola, cholera, and the most dangerous pandemic, Covid-19, are all fatal pandemics. It was said that Coronavirus started spreading from Wuhan, China. The virus then afflicted the entire human race worldwide. The major goal of this paper is to compare the most catastrophic pandemic to another pandemic in terms of its effect on GDP. This study also examined the impact of the pandemic on the stock market. We offer a descriptive examination of economic impact over the course of 19 years for different countries