This chapter highlights the integration of Lean Six Sigma (LSS) and Industry 4.0 (I4.0) concepts in today’s scenario to offer complementary benefits. I4.0 has changed the way production systems function, making tools like LSS more important than ever before for continuous process improvement. Ingenious I4.0 tools support the data-driven methods employed in LSS. Furthermore, enhancing processes may help businesses make better use of cutting-edge technology, such as those used for collecting and analyzing data. Collecting and analyzing data is a cornerstone of quality improvement methods used to address existing problems with quality. Combining the principles of Lean Manufacturing with the six-sigma methodology may help to reduce process variance and, in turn, improve quality. With robust data analysis methodologies that can wring useful insights from accessible big data, I4.0 is moving in the direction of digitalizing industrial operations. It is feasible to drive meaningful choices by employing these strategies in each and every phase of LSS cycles.