Purpose
This study aims to examine current research on the relationship between Operational Excellence and Healthcare 4.0 (H4.0) for healthcare organizations.

Design/methodology/approach
The authors have performed a systematic literature review of 102 documents published between 2011 and 2022 from the Scopus database to identify the research trends on Operational Excellence and H4.0. Through a descriptive bibliometric analysis, this study has highlighted the year-wise trend in publication, top authors, prominent sources of publications, the country-wise spread of research activities and subject area analysis. Furthermore, through content analysis, this study has identified four clusters and proposed directions for future research of each identified cluster.

Findings
Results reflect overall growth in this area, with a few parts of the world being underrepresented in research related to Operational Excellence and H4.0. The content analysis focused on describing challenges pertaining to healthcare industries and the role of Operational Excellence tools and H4.0 technologies in dealing with various healthcare delivery aspects. The authors concluded their analysis by proposing a theoretical framework and providing theoretical and managerial implications of the study.

Originality/value
To the best of the authors’ knowledge, the paper is one of the first to analyze the existing literature on the healthcare sector at the interface of Operational Excellence and H4.0 technologies. The conceptual framework and cluster-wise future research prepositions are some of the unique offerings of the study.