The work-from-home practices initiated during the COVID-19 pandemic have caused a paradigmatic shift in how we work. Work from home (WFH) led to an intermingling of the domestic and professional spaces, and the WFH phenomenon has asymmetrically impacted women’s work. In such a scenario, women professionals experience a greater work–life conflict, and the significance of family support comes to the fore. Studying this phenomenon in the Indian context is interesting because the primary responsibility for Indian women lies in the domestic arena. Female Indian professionals are expected to seamlessly fulfil their domestic duties no matter how demanding their job is. The multiplicity of challenges that affect women professionals’ productivity at work only gets compounded when women are expected to work from the domestic sphere where the demand of domestic duties constantly confronts them. Several global scholars have indicated that the burden of domestic duties was greater for women during the COVID-19 pandemic, and the burden of child-care, elderly care and cooking activities increased as outsourcing such activities was not an easily available option during the lockdowns which led to reduced work productivity amongst women. However, this study revealed that Indian female professionals reported better work productivity than female professionals working from their workspace. Indian women are used to fulfilling domestic and professional duties even prior to the pandemic, and Indians perceive greater satisfaction in interpersonal relational experiences rather than individualistic career goals. The study also revealed that family support did not increase when women were working from home, but the increase in family support increased women’s work productivity. Findings also indicate that female professionals with children showed significantly lower work productivity than female professionals (married and unmarried) without children.