This study is of great clinical and timely relevance, also adhered the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Furthermore, it is also recommended that the Protocol OF A Systematic Review and Meta-Analysis be registered in the International Prospective Register of Systematic Reviews (PROSPERO) to identify any replication of the study and act as guide for other similar studies. We would like to take the opportunity to offer our perspective and constructive critique in their analysis.