Over the past decade, there has been a constant spotlight on introducing sustainability in the supply chain (SC). The materialistic human greed for production and consumption has led to a radically increased level of greenhouse gases. SC has become its principal contributor. We are addressing this socio-economic environmental challenge by developing a multi-stakeholder framework and focusing on a knowledge-based net zero supply chain, as there are no concrete existing studies that have investigated current state-of-the-art operations in this relevant field. Therefore, this research has been conducted to investigate the drivers, barriers and practices through which net zero economy (NZE) can be attained in a knowledge-based SC. In this regard, the paper conducts an exploratory systematic review of selected articles from peer-reviewed journals. The findings indicate that primary stakeholders (i.e. organisations and suppliers) require to take an active role in bringing about sustainable changes in practice. However, external perspectives (i.e. government, society, consumers and community) have also been identified as sources that create challenges as well as have the potential to aid sustainable industrial practices. Additionally, progress can be enhanced through proper policies, regulations and a knowledge-based conceptual framework to pave the way for a sustainable environment. Proper practices for NZE also provide scope for economic growth through cost-effective production. This paper will be beneficial for practitioners as well as policy makers on a global scale who aim to attain NZE for sustainability