This chapter considers the effects of spirituality as well as meaning and purpose on the quality-of-life and more specifically in the workplace subjective well-being, under the umbrella of the adaptability construct. Facing life challenges and changes may often be overwhelming and stressful. People learn that to deal with challenges and changes, they must become adaptable. This means that they must either have or develop the ability, purpose, and means to regulate their personal (mental, emotional, and behavioral) resources to achieve subjective well-being. Meaning and purpose are claimed to be a psychological well-being factor that often plays a regulatory role which can be described as the motivational propeller aiming for gratifying future endeavors and plans. Spirituality commonly is described as one’s ensuing life with meaning and purpose, and it is a notion, concept, and enlightenment that consequently leads to self-transcendence. It can rightfully be deduced that spirituality and meaning and purpose are cognate constructs. Emerging research on workplace spirituality has shown that workers, who find meaning in their work, function effectively and attain greater satisfaction in their work–life, which may also generate higher profitability for enterprises. The following analysis will demonstrate the relationship among meaning and purpose, spirituality, and adaptability and then the significant outcomes of those factors on workplace well-being. Accordingly, it will be conferring the role of workers’ spiritual beliefs at work for business organizations and society as a whole