In this paper we give 91 hypotheses and 6 conjecturers that relate various aspects of Information Technology / Systems (IT/S) as related to the strategy of the firms (cost leadership, differentiation and innovators). These are virtual teams (VTs) in track 1, enterprise social media (ESM) in track 2, analytics, strategy of organization (cost leadership/differentiation) and types of innovators (continuous innovation, modular innovation, architectural innovation and radical innovation) in track 3 and machine learning, artificial intelligence, types of programming (OOP, extreme and scrum) and internet of things (IoT) in track 4. These are new hypotheses and have tremendous implications for top management of firms as they go about managing its IT/S infrastructure.