With the increase in the popularity and a promising revenue model of esports,theissue of e-doping has emerged. Some esports athletesmaydesire to deliver an outstanding performance to get an advantage over other competitors with the help of „cheat software‟. The paper exploresvarious forms of e-doping such as disruption of live streams, attacking serversand discusses how these methods are a challenge to the spirit of fair play. E-doping can take two forms: the use of hardware of software hacks to gain an unfair advantage, or the use of performance enhancing substances. To curb the menaceof e-doping, different esportsassociations have usedanti-cheating software such asValue Anti-Cheat(VAC), which monitors and tracks the movement of the player‟s input devices, by which a player could manipulate theirmoves. The establishment of the International Esports Federation (IESF) and the Esports Integrity Coalition (ESIC) have seen some progress in the regulation of integrity issues in esports. Following the public admission of Kory “Semphis” Friesen in 2015, of using Adderall during a tournament of Counter Strike, ESL (an esports company) collaborated with the World Anti-Doping Agency (WADA)to develop the first anti-doping policy. Unfortunately, the implementation of this policy has not been effectiveas it could be, due to non-cooperation from different esports companies. In addition, this policy focuses on the use of banned substances, rather than other forms of in-game cheating. Consequently,the authors recommend reforms to e-doping policies. In addition, the authors further the debate about the importance of an improved governance structure which will assist the stakeholders to tackle the menace of e-doping, thereby promoting the principles of fair competition.