This chapter explores the paradigm shift in Human Resources (HR) from reactive, intuition- based practices to a proactive, data- driven function powered by Cloud-native Artificial Intelligence (AI). It argues that the synergy between cloud computing's scalability and AI's predictive capabilities is fundamental to reimagining talent management. The chapter deconstructs the modern predictive HR tech stack and presents core use cases in acquisition, retention, development, and performance. It critically addresses the imperative of navigating ethical challenges—including bias, privacy, and transparency—and provides a framework for responsible implementation. Ultimately, this evolution empowers HR to become a strategic partner, using predictive analytics to augment human decision- making, mitigate workforce risks, and foster a more adaptive, resilient, and human- centric organization. © 2026 by IGI Global Scientific Publishing. All rights reserved.