In the post-pandemic period, global supply chain (SC) operations are increasingly affected by geopolitical tensions, rising inflation, and logistical difficulties. Organizations located in different regions continue to struggle with SC disruptions, facing challenges related to planning and operational stability. One of the major challenges is developing an SC that remains stable during disruptions, fulfills customer demands, and contributes to overall business expansion. But, at the same time, SC faces increasing disruptions due to global complexities, demand volatility, and sustainability pressures. Therefore, organizations are adopting digital technologies in their operations to enhance resilience by anticipating risks, responding quickly, and ensuring continuity of operations. The knowledge of SC is still limited in the Industry 4.0 (I4.0) context. Therefore, this study initially investigates the role of I4.0 technologies to reshape supply chain resiliency (SCR), with a focus on enhancing agility and ensuring long-term sustainability within evolving market conditions. The study highlights key factors required to develop SCR. Further, the study uncovers the inter-dependencies, relationships, and priority of factors by using a hybrid approach. It is found that top management support is the most critical factor in building SCR. The present study contributes to the existing literature on SCR by providing novel insights into the theory, managerial implications, practical applications, and policy considerations for developing SCR.