With the growing integration of artificial intelligence (AI) in education, its potential to support students with disabilities in higher education remains significant but underexplored. This systematic review synthesizes existing literature on AI's effectiveness, barriers, and implications for inclusive education. Using the sample, phenomenon of interest, design, evaluation, and research type (SPIDER) framework, studies published between 2013 and 2024 were identified through a systematic search in databases such as PubMed, Scopus, Embase, Cochrane Library, and Google Scholar. Eighteen studies met the inclusion criteria, focusing on higher education settings and students with disabilities. The findings emphasize AI's role in enhancing accessibility, personalizing learning experiences, and fostering inclusiveness. However, persistent challenges include technological barriers, ethical concerns, and insufficient training. While AI holds transformative potential to support students with disabilities in higher education, addressing infrastructure gaps and ethical and training deficiencies is crucial for sustainable implementation and equitable learning environments.