Digital Transformation has significantly impacted on the supply chain performance and sustainability of business organizations. In today’s competitive landscape, organizations are pressured to meet customer expectations in the ongoing digital transformation initiatives. This research investigates the integration between digital transformation, operational excellence, and sustainability within business organizations. By examining existing literature and synthesizing insights from diverse sources, the study seeks to explain the transformative potential of digital technologies in reshaping operational processes and driving sustainability initiatives. Findings reveal that digital transformation is a strategic enabler for achieving operational excellence within organizations. Through process automation, datadriven decision-making, seamless integration, customer-centricity, and agile operations, businesses can optimize processes, enhance productivity, and deliver superior customer experiences. Also, digital transformation facilitates sustainability initiatives by promoting resource efficiency, enabling remote work practices, fostering green technologies, ensuring supply chain transparency, and implementing circular economy principles. By leveraging digital technologies, businesses can enhance competitiveness, navigate market complexities, and contribute to environmental stewardship.