Disruptive technologies have transformed supply chain (SC) operations into automated SC. However, SC firms still lack transparency and accuracy in SC networks and work under high-risk conditions. In this direction, a cyber-physical fusion architecture is proposed to gain interoperability and technical integration between the cyber and physical worlds, resulting in a resilient SC. The core components of the architecture include a cyber-physical production system (CPPS), big data, augmented reality/virtual reality (AR/VR), additive manufacturing (AM), and incorporation of blockchain technology (BCT), which provide a realistic solution for traditional SC models to mitigate risk. This study highlights the proposed cyber-physical fusion architecture that can lead to SC innovation and reconfiguration in the digital era. The objective of this study is to explore the potential opportunities of the proposed architecture through which SC performance can be enhanced by capturing real-time data, SC risks, disruptions, product visualization, or logistic tracking that can be accessed by edge services or portable terminals. It is underlined that adopting the proposed architecture will synchronize and resilient the SC and provide many provisions for cost reductions, controlled carbon emissions, and optimal usage of resources to mitigate risk. This chapter presents a cyber-physical fusion architecture with the extant literature on integrated SC and Industry 4.0, its functional implementation, opportunities, and future perspectives.