Industries undergoing rapid digital transformation are facing a significant global challenge: a widening gap between required and available workforce digital skills. This study identifies key determinants of this gap and develops a comprehensive conceptual framework for mitigation. The research adopted a mixed-methods strategy, integrating expert insights through interviews and a PRISMA-informed systematic review of existing literature. The findings identify critical enablers, including accessible digital infrastructure, targeted investments in skilling, inclusive policies, government-led digital literacy initiatives, industry-aligned curricula, and organizational digital maturity. In contrast, key barriers include limited access to quality educational resources, outdated curricula, high infrastructure costs, and inadequate regulatory support. Further, integrating the Resource-Based View and Technology Acceptance Model, Technology–Organization–Environment frameworks, we propose a novel conceptual model capturing organizational and individual factors influencing skill acquisition. This framework elucidates the complex dynamics driving digital skill gaps and provides actionable guidance for designing inclusive, future ready upskilling strategies. Our findings offer vital insights for researchers, HR leaders, educators, and policymakers building resilient, digitally competent workforces for Industry 4.0 and beyond.