Purpose – In the present scenario of global competition and economic recession, most of the organizations are facing a tough challenge to survive in the market because of shortening product life cycle and reducing profit margin. Customers are seeking better design, production, and delivery, which have made firms to concentrate on flexibility in supply chains. Therefore, the purpose of this study is to identify major factors and develop a suitable framework for flexibility in supply chains. Design/methodology/approach – Based on literature review, about 14 factors have been identified. To develop a relationship with these factors, a team of five experts from industry and academia was formed. Based on inputs from experts, different relationships are developed among factors to form structural selfinteraction matrix (SSIM). Based on this matrix, a flexibility framework is developed by interpretive structural modelling approach. Findings – Top management commitment, strategy development for flexible SC, application of advanced technology and IT tools, information sharing in SC members, trust development among supply chain members have emerged as major driving factors. Logistics and warehouse management, suppliers flexibility, distribution flexibility and manufacturing flexibility have emerged as dependent factors. Research limitations/implications – Framework developed in this study is based on interpretive structural modelling. This framework can be further validated with some case analysis and empirical findings. Originality/value – Findings of the study can be useful for industry professionals to develop strategies for flexible supply chains. It will help them in taking new initiatives for making supply chains more responsive and proactive for customers demand.