This Article regionalizes the discourse on the evolutive interpretation of human rights treaties to Africa. In it, three broad issues are discussed. First, it discusses the extent to which the African Human Rights Commission and Court may adopt the evolutive interpretation in interpreting the African Charter. Second, it examines the challenges to this interpretation method. Third, it discusses the counterarguments to the challenges. The Article argues that two main groups of provisions may support an evolutive interpretation of the African Charter – the “any other status” clause in Article 2; and Articles 60 and 61, referred to as the “decompartmentalization articles.” It finds that the popular notion that evolutive interpretation is contrary to the traditional international law principle of intent and consent and the potential clash of evolutive interpretation with African values are the main challenges to adopting the evolutive interpretation of the African Charter. In turn, the Article provides counterarguments to these challenges.