The current study describes the design analysis and implementation for the Cascode Class-F Power Amplifier (PA) Sub-6-GHz Massive MIMO Application. The reconfigurable Microstrip differential filter (RMDF) is selected for providing high efficiency. A RMDF technique is utilized to enhance the gain of 13.5 dB and improve the resonance band operation. The design verified 10 to 35.8 dBm of power output & added power efficiency of (PAE) of 69.4%. The designed PA presents a significant enhancement in new IOT transmitter for medical industry. The applications of the current study can be used for wireless 5G technology, multiple data signaling for antenna application, multiple radio-link for radio receiver.