Epicardial adipose tissue and cardiac lipotoxicity: A review

Mukherjee, Anirban Goutam, Renu, Kaviyarasi, Gopalakrishnan, Abilash Valsala, Jayaraj, Rama, Dey, Abhijit, Vellingiri, Balachandar and Ganesan, Raja (2023) Epicardial adipose tissue and cardiac lipotoxicity: A review. Life Sciences, 328: 121913. pp. 1-13. ISSN 0024-3205

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Epicardial adipose tissue (EAT) has morphological and physiological contiguity with the myocardium and coronary arteries, making it a visceral fat deposit with some unique properties. Under normal circumstances, EAT exhibits biochemical, mechanical, and thermogenic cardioprotective characteristics. Under clinical processes, epicardial fat can directly impact the heart and coronary arteries by secreting proinflammatory cytokines via vasocrine or paracrine mechanisms. It is still not apparent what factors affect this equilibrium. Returning epicardial fat to its physiological purpose may be possible by enhanced local vascularization, weight loss, and focused pharmacological therapies. This review centers on EAT's developing physiological and pathophysiological dimensions and its various and pioneering clinical utilities.

Item Type: Article
Keywords: Cardiovascular Disease | Epicardial Adipose Tissue | Free Fatty Acids | Lipotoxicity | PPAR-Γ
Subjects: Social Sciences and humanities > Social Sciences > Health (Social sciences)
JGU School/Centre: Jindal Institute of Behavioural Sciences
Depositing User: Amees Mohammad
Date Deposited: 19 Jul 2023 04:10
Last Modified: 19 Jul 2023 04:33
Official URL: https://doi.org/10.1016/j.lfs.2023.121913
URI: https://pure.jgu.edu.in/id/eprint/6345


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