Recent advances in understanding brain cancer metabolomics: A review

Mukherjee, Anirban Goutam, Gopalakrishnan, Abilash Valsala, Jayaraj, Rama, Ganesan, Raja, Renu, Kaviyarasi, Vellingiri, Balachandar, Dey, Abhijit and Parveen, Mohamudha (2023) Recent advances in understanding brain cancer metabolomics: A review. Medical Oncology, 40 (8): 220. pp. 1-12. ISSN 1357-0560

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Regardless of the significant progress made in surgical techniques and adjuvant therapies, brain tumors are a major contributor to cancer-related morbidity and mortality in both pediatric and adult populations. Gliomas represent a significant proportion of cerebral neoplasms, exhibiting diverse levels of malignancy. The etiology and mechanisms of resistance of this malignancy are inadequately comprehended, and the optimization of patient diagnosis and prognosis is a challenge due to the diversity of the disease and the restricted availability of therapeutic options. Metabolomics refers to the comprehensive analysis of endogenous and exogenous small molecules, both in a targeted and untargeted manner, that enables the characterization of an individual’s phenotype and offers valuable insights into cellular activity, particularly in the context of cancer biology, including brain tumor biology. Metabolomics has garnered attention in current years due to its potential to facilitate comprehension of the dynamic spatiotemporal regulatory network of enzymes and metabolites that enables cancer cells to adapt to their environment and foster the development of tumors. Metabolic changes are widely acknowledged as a significant characteristic for tracking the advancement of diseases, treatment efficacy, and identifying novel molecular targets for successful medical management. Metabolomics has emerged as an exciting area for personalized medicine and drug discovery, utilizing advanced analytical techniques such as nuclear magnetic resonance spectroscopy (MRS) and mass spectrometry (MS) to achieve high-throughput analysis. This review examines and highlights the latest developments in MRS, MS, and other technologies in studying human brain tumor metabolomics.

Item Type: Article
Keywords: Brain | Cancer | Metabolites | Metabolomics | Tumor
Subjects: Physical, Life and Health Sciences > Medicine
JGU School/Centre: Jindal Institute of Behavioural Sciences
Depositing User: Amees Mohammad
Date Deposited: 17 Jul 2023 06:54
Last Modified: 27 Sep 2023 05:42
Official URL:


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