This design explores the analysis and implementation to a reconfigurable harmonic matching technique with Cascode Class-F Power Amplifier (PA) for IoT-enabled healthcare application. The special circuit efficiency and extended digital pre-distortion are taken to select for providing high efficiency and high linearity properties. A compact gallium nitride (GaN) Class F PA is developed as a proof of concept, using a reconfigurable harmonic network to demonstrate its broadband characteristics. A reconfigurable harmonic matching technique is utilized to enhance the gain up to 19.3 dB to the saturation power region. and improve the resonance band operation. The design verified maximum range of output power of 20 to 43dBm at 74.5% and power added efficiency (PAE) of 67.8%. The harmonic balance of fundamental & second balance is showed from -21dBc to - 16dBc.