Cytotoxic Effects of Nanoliposomal Cisplatin and Diallyl Disulfide on Breast Cancer and Lung Cancer Cell Lines

Gunasekaran, Kaavya, Vasamsetti, Bala Murali Krishna, Thangavelu, Priyadharshini, Natesan, Karthi, Mujyambere, Bonaventure, Sundaram, Viswanathan, Jayaraj, Rama, Kim, Yeon-Jun, Samiappan, Suja and Choi, Jae-Won (2023) Cytotoxic Effects of Nanoliposomal Cisplatin and Diallyl Disulfide on Breast Cancer and Lung Cancer Cell Lines. Biomedicines, 11 (04): 1021. ISSN 2227-9059

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Dual drug delivery has become the choice of interest nowadays due to its increased therapeutic efficacy in targeting the tumor site precisely. As quoted in recent literature, it has been known to treat several cancers with an acute course of action. Even so, its use is restricted due to the drug’s low pharmacological activity, which leads to poor bioavailability and increases first-pass metabolism. To overcome these issues, a drug delivery system using nanomaterials which would not only encapsulate the drugs of interest but also carry them to the target site of action is needed. Given all these attributes, we have formulated dual drug-loaded nanoliposomes with cisplatin (cis-diamminedichloroplatinum(II) (CDDP)), an effective anti-cancer drug, and diallyl disulfide (DADS), an organosulfur compound derived from garlic. The CDDP and DADS-loaded nanoliposomes (Lipo-CDDP/DADS) exhibited better physical characteristics such as size, zeta potential, polydispersity index, spherical shape, optimal stability, and satisfactory encapsulation percentage. The in vitro anti-cancer activity against MDA-MB-231 and A549 cell lines revealed that Lipo-CDDP/DADS showed significant efficacy against the cancer cell lines, depicted through cell nucleus staining. We conclude that Lipo-CDDP/DADS hold exceptional pharmacological properties with better anti-cancer activity and would serve as a promising formulation to treat various cancers.

Item Type: Article
Keywords: Anti-Cancer Therapy | Cisplatin | Diallyl Disulfide | Nanoliposome
Subjects: Physical, Life and Health Sciences > Biology
JGU School/Centre: Jindal Institute of Behavioural Sciences
Depositing User: Amees Mohammad
Date Deposited: 08 May 2023 04:06
Last Modified: 08 May 2023 04:06
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