Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies

Leung, Yvonne, Barzilai, Nir, Batko-Szwaczka, Agnieszka, Beker, Nina, Boerner, Kathrin, Brayne, Carol, Brodaty, Henry, Siu-Lan Cheung, Karen, Corrada, María M., Crawford, John D., Galbussera, Alessia A., Gondo, Yasuyuki, Holstege, Henne, Hulsman, Marc, Ishioka, Yoshiko and -, et al (2022) Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies. Alzheimer's and Dementia, 19 (6). pp. 2265-2275. ISSN 1552-5279

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Abstract

Introduction: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. Methods: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. Results: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). Discussion: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

Item Type: Article
Keywords: Centenarians | Dementia | Education | Exceptional Longevity | Prevalence | Risk Factors
Subjects: Physical, Life and Health Sciences > Medicine
Physical, Life and Health Sciences > Neuroscience
JGU School/Centre: Jindal School of Liberal Arts & Humanities
Depositing User: Amees Mohammad
Date Deposited: 06 Dec 2022 05:19
Last Modified: 23 Jun 2023 04:23
Official URL: https://doi.org/10.1002/alz.12828
Funders: NHMRC Australia
Additional Information: The authors acknowledge the contribution of the late Professor Bo Hagberg from Lund University, who was a founding member of the international centenarian consortium and had offered invaluable data from the Swedish Centenarian Study for this paper. In addition, we wish to acknowledge the contribution of Dr Thomas Marlow from the University of Gothenburg, who was involved in data sharing and review of earlier drafts of this manuscript. We also thank Ms Catriona Daly, who is a former coordinator of the ICC-Dementia, for her contribution to the early work on the consortium and this project. The funding was supported by NHMRC Australia program grant 1093083. Individual cohorts funded by local funding bodies.Open access publishing facilitated by University of New South Wales, as part of the Wiley - University of New South Wales agreement via the Council of Australian University Librarians.
URI: https://pure.jgu.edu.in/id/eprint/4974

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