Heavy metal pollution has silently insinuated itself into the fabric of modern life – from the vegetables on our dinner plates and the tap water we drink to the cosmetics we use daily. This reality underscores global environmental and public health crises intensified by industrialization and urban expansion. Conventional physical and chemical remediation methods for heavy metals, while effective to a degree, often involve prohibitive costs and risk disrupting the delicate balance of the original ecosystem. Consequently, the search for green, sustainable, and economically viable remediation alternatives has become imperative. This special issue brings together nine cutting-edge research papers that explore recent advances in heavy metal pollution control and resource recovery from diverse angles – including microbial remediation, plant–microbe combined approaches, bioleaching for resource utilization, soil amendment applications, and the ecological toxicity of nanoparticles. Collectively, these studies offer theoretical insights and novel practical strategies to support the development of efficient and sustainable technologies for managing heavy metal contamination. These research results can pave the way for deeper investigation into the efficacy of the proposed remediation with the eventual aim of taking the science from the lab to the field.