The “Pradhan Mantri Bhartiya Janaushadhi Pariyojana” (PMBJP) aims at enhancing the accessibility of basic medicines in terms of geographic and economic efficiency through promoting generic preparations. The data were collected from 90 respondents and 17 doctors and experts in medical sciences. The current research paper broke down the hierarchical structure and interdependent relationships of these barriers by implementing the technique of the Modified Total Interpretive Structural Modelling (m TISM) along with MICMAC analysis. Up-stream restrictions, in their turn, extended downwards, disrupting the variables of operations, including constrained availability, suppressed public awareness and fears related to the quality of medicines, and eventually create resistance among stakeholders and apprehension among consumers in the case of migrating to generic therapies. The investigation provided the practical knowledge that was the most relevant in overcoming systemic obstacles in the work of the public health interventions, matching its research results with the known frameworks of the publicpolicy implementation. Practical implications of this study were that it was essential to undertake comprehensive policy changes, optimal fiscal stimulus, robust supply-chain management, and carefully focused educational promotion to enhance the speed of adoption and effectiveness of PMBJP. This study had a significant value to the academic conversation about the issue of the public health policy in India as it systematically outlined and classified the factors that obstruct the implementation of PMBJP.