The present food supply chains confront a variety of social, environmental, and economic issues. One major consequences of these difficulties are post-harvest losses (PHL) in perishable food supply chains (PFSCs). Due to still less evolved business conditions and practices, PFSC struggles with PHL and lacks a clear understanding of the approaches they might use to reduce PHL. The current article focuses on developing solutions to manage PHL and its causes in PFSCs. A normative review is used to identify the broad strategies for the mitigation of PHL. Strategies to mitigate PHL are identified from content analysis of the literature. It identifies and discusses nine strategies, such as Improved Storage and Handling across FSC, Supply Chain Optimization, Enhanced Processing Techniques, Optimized Harvesting Timing, Proper Handling Practices, Education and Training, Temperature Control, Research and Development, and Pest and Disease Management. Nine key strategies were identified using Best–worst Method. The article collates various viewpoints from the experts regarding how the identified strategies were operationally different in developing countries as compared to developed economies, thus presenting a holistic image for PHL mitigation in a developing economy. Mitigating PHL and the reverse flow of wasted nutrition are critical for circular economy realization. There is a strong need to take a nutrition perspective of FSCs and research into improving the nutritional efficiency of the existing FSCs.