The main objective of the paper is to present a holistic approach for finding the NPA’s causes in emerging and developed countries of commercial banks. The research paper used two step system generalized method of moments model has been used for finding the factors of non-performing loans in banks. A comparative analysis of findings suggests that inflation and unemployment rate among the macro-economic factors and lagged NPL, loan to deposit ratio, profitability, firm size, and bank capital among the bank specific factors exhibit that causes for NPLs, in Group 2 countries namely: Italy, India, Ireland, and Croatia. In addition, regulatory quality, government effectiveness, control of corruption and political stability & absence of violence also significantly contributed to control the NPLs in Group 1 countries namely: China, Indonesia, Malaysia and the Philippines. This chapter not only provides a detailed analysis for causes non-performing loans of banks by macro- and bank-specific factors but also examine causes of country governance factors over non-performing loans. This is actually preliminary analysis about present study and in future would like to expand other parameters as well.