The global food system faces a significant threat due to its substantial connections to greenhouse gas emissions, necessitating the exploration of sustainable alternatives. Amidst the prevalent realisation and responsiveness toward overcoming this adverse impact, mushroom farming (MF) has emerged as a promising solution for soil conservation, food security, and meeting sustainable environment goals. This study explores enablers to MF by reviewing the extant literature and conducting expert interviews. Further, the study employs Interpretive Structural Modelling (ISM) to capture the complex interdependencies among these enablers and understand potential strategies to leverage them as opportunities. Findings reveal that low technological requirements, flexibility in farming systems, nutritional security, and the versatile application of spent mushroom substrate are the most influential drivers of MF adoption. These insights provide a structured understanding of the multifaceted opportunities embedded in MF and highlight its potential to align with India's sustainability and food security goals.